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KMID : 0613820200300110965
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Journal of Life Science
2020 Volume.30 No. 11 p.965 ~ p.972
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Physiological Activity of Methanol Extracts from Sambucus sieboldiana var. miquelii (Nakai) Hara
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Oh Yu-Jin
Cho Hae-Jin
Woo Hyun-Sim
Byeon Jun-Gi
Kim Yeong-Su
Kim Dae-Wook
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Abstract
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Sambucus sieboldiana var. miquelii (Nakai) Hara is distributed in Korea, China, and Japan, and has been used as an anti-rheumatic in folk medicine in oriental countries. The present study aims to investigate the potential use of this species in health functional foods, cosmetics, and food preservatives. Methanol extracts of leaves and branches from this plant were prepared to quantitatively analyze the total phenol and flavonoid contents, and to investigate the antioxidative and enzyme inhibitory activities, and the inhibition of nitric oxide (NO) production activity. The results showed that the total polyphenol and flavonoid contents of the crude extract were 1.52±0.1 mg/g and 1.73±0.1 mg/g, respectively. S. sieboldiana polyphenols exhibited potent scavenging activity shown by 2, 2’-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay and 2, 2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation assay. The crude extract also exhibited significant α-glucosidase and tyrosinase inhibitory activity with IC50 values of 183.5 μg/ml and 323.9 μg/ ml, respectively. Additionally, the crude extract exhibited strong anti-inflammatory activity determined through the nitric oxide inhibition assay in a dose-dependent manner with an IC50 value of 36.7 μg/ml and no cytotoxic effect on the macrophages. Therefore, we demonstrated that the leaves and branches of S. sieboldiana extract possess antioxidant, anti-diabetic, depigmentation potential, and NO production inhibitory activities. According to recent research, S. sieboldiana has great potential as a source of the bioactive compound which could be used as food, cosmetics, and pharmaceutical agents.
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KEYWORD
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α-Glucosidase inhibitory activity, anti-inflammatory effect, antioxidant, Sambucus sieboldianavar. miquelii (Nakai) Hara, tyrosinase inhibitory activity
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